30 day supply
GMP Certified
3rd Party Tested

Natural Spermidine ∘ 700mg per serving

Natural Spermidine to renew your cells, restore hair & skin, and support healthy ageing

Brain Health
Longevity
Heart Health
Free quick delivery worldwide

Accreditations

Ultra pure, high-grade ingredients only Naturally sourcedClinical-strength daily doseMicronised for maximum absorbencyLab-grade, UV safe amber glass vessel
 

✓ Supports autophagy, your body's cellular clean-up process

✓ Supports brain function & mental clarity

✓ Supports heart & cardiovascular health

✓ Supports healthy hair & skin

✓ Promotes healthy ageing & longevity

Long term supplementation is linked to longer lifespan in multiple studies.

Contains 60 capsules. One capsule contains 350mg of Spermidine-rich natural Wheatgerm Extract.

The capsule shell is made from 100% vegetable cellulose.

  • NOTE: CONTAINS GLUTEN
  • Vegan and Vegetarian
  • Non-GMO
  • Allergen Free
  • Halal / Kosher Friendly

For maximum effectiveness, take two capsules daily with a meal for optimal absorption. For best results, complement your routine with a balanced diet rich in healthy fats.

Spermidine can be taken at any time of day; however, taking it at the same time every day is recommended.

This product is intended for use by healthy adults only. Do not take if you are pregnant or breastfeeding. Our Spermidine is produced from wheat germ extract, and therefore contains gluten. It is not suitable for individuals with celiac disease or gluten intolerance.

For best results, complement your supplement routine with a balanced diet. Always consult with your doctor or healthcare professional before beginning any supplement, and never exceed the recommended daily dose.

UK ORDERS:

  • Standard Delivery (FREE):Delivered via Royal Mail 48H service.
  • Express Delivery (£3.95): Delivered via Royal Mail 24H service..

INTERNATIONAL ORDERS:

  • Standard Delivery (FREE): Delivered via Fedex Economy Services, 3-7 days.
  • Express Delivery (£3.95): Delivered via Fedex Prioirty Services, 2-4 days.

We are proud to cover customs, duties and taxes for our international customers.

Manapura delivers high-strength natural spermidine capsules, Supporting healthy ageing and autophagy, the body’s natural cellular clean-up process.

Ultra Pure

Extracted naturally - with absolutely no synthetic additives or fillers

Medical Grade

We make our supplements in certified facilities (cGMP & ISO 9001) the same standards used for best-in-class pharmaceuticals.

Micronised For Maximum Absorption

Our formulas are processed into tiny particles (micronised) so your body can absorb it more easily.

Vegan

Purposefully suitable for most diets, our zero-tolerance for additives gives you the cleanest form that the body recognises and can absorb.

Manapura® VS Most Brands On The Market

Natural Spermidine Supplement FAQs

What is Spermidine, and how does it work?

Spermidine is a natural polyamine that promotes autophagy, the body’s cellular renewal process.

How long do I need to supplement for to achieve the benefits?

Long term supplementation is linked to longer lifespan in multiple studies.

What is autophagy and why is it important?

Autophagy is the body’s natural clean-up process. It recycles dysfunctional cell components, supports energy efficiency, and protects against age-related disease.

Does your Spermidine contain gluten?

Yes. This product is a natural wheatgerm extract, which contains Gluten, and so should not be taken if you are Gluten intolerant.

Is Spermidine safe to take?

Yes, Spermidine is naturally found in the body and considered safe at recommended doses, although as noted above this product contains Gluten.

How should I take Spermidine?

Take 2 capsules daily, preferably with a source of fat for enhanced absorption.

What is Spermidine, and how does it work?
How long do I need to supplement for to achieve the benefits?
Can Spermidine improve longevity?
What is autophagy and why is it important?
Does your Spermidine contain gluten?
Is Spermidine safe to take?
How should I take Spermidine?

Every single batch is tested by third-party labs.

Batch tested for heavy metals, toxins, and unwanted contaminants. Nothing gets shipped unless it meets the highest safety standards.

  • 5 stars: 18 (95%)
  • 4 stars: 1 (5%)
  • 3 stars: 0 (0%)
  • 2 stars: 0 (0%)
  • 1 star: 0 (0%)
Some of the reviews shown are from related products the merchant grouped with this one.
A
Anonymous

Excited to add such high quality Spermidine to my stack.

R
Radcliffe

Been taking spermidine with NMN. Certainly more energy. Also a quick delivery

M
Michelle N.

Just started taking this currently feel great. I will write another review in the next couple of months.

A
Anonymous

I take their Spermidine & Fisetin for Autophagy. Steady improvements with energy. Decent brand

R
Raymond

arrived within 2 days in very sleek packaging. great supplements

J
Joan

Taking Spermidine with Fisetin and feeling a lot sharper generally. Love the packaging

A
Anonymous

Definitely feeling more energised and less inflammation.

H
Holly A.

Taking this as part of my plan to look 25 at 55, so far so good

L
Lottie P.

10/10

C
Customer
Natural Spermidine

Interesting product, I'm new to this stuff but find the science behind this one quite interesting, don't think anything else I take does the same thing so will keep trying it.

J
Joe L.
Natural Spermidine

Bought the Spermidine supplements with the Fisetin for maximum senolytic power! Recommend all lognevity enthusiasts to look into the benefits, lots of solid studies out there.

B
Ben M.
Natural Spermidine

Bought as part of the trio as I wanted Fisetin, glad to support a UK brand with better credentials

K
Kieran B.
Natural Spermidine

Pretty good pricing when bought as a set for the quality - and the order came very quick too. Will repurchase.

J
James R.
Natural Spermidine

Very happy, was looking for a strong dose. Surprisingly nice packaging.

J
James P.
Natural Spermidine

Came quick and nice packaging, will buy again when this runs out

H
Harriet J.
Natural Spermidine

Manapura Spermidine offers a solid dose at a fair price. After a few weeks, I've noticed clearer focus and steady energy. Knowing it supports autophagy and healthy ageing makes it feel like a smart, well-formulated addition to my routine. No side effects so far.

D
Dominic P.
Natural Spermidine

I'm 40 and started taking spermidine after reading about its link to cellular renewal and healthy ageing. I wasn't expecting a dramatic overnight change, but after about six weeks I've really noticed the difference.

I feel sharper in the mornings, my focus at work is better, and even my recovery after workouts seems quicker. Friends have commented that my skin looks fresher, which is a nice bonus.

I like knowing that I'm supporting my long-term health, not just chasing a quick fix. The capsules are easy to take and I've had no side effects at all.

If you're around my age and starting to think about staying in top form for the next few decades, give it a try.

H
Hannah K.
Natural Spermidine

Bought this as part of the Cellular Renewal Set as I needed Berberine + Fisetin anyway, but since taking Spermidine I've really noticed my hair feeling much healthier and softer, not sure if it's as a result of taking them all in tandem but I'll take it!

J
James H.
Natural Spermidine

Been taking the Manapura Spermidine for 3 weeks and my hair and skin are noticeably healthier. I'm using this as part of my longevity protocol, and this feels liike a bit of a secret weapon.

Meet our Advisors

Dr. Cherry Lo, Ph.D., is a researcher specialising in pathology and immunity, with degrees from CUHK and the University of Hong Kong. Her work focuses on the interaction between NK cells and rheumatoid arthritis, providing new insights into disease mechanisms. As a research scientist, she contributes to advancements in longevity science. With a passion for immunology and translational research, Dr. Lo is dedicated to uncovering innovative solutions for age-related diseases and immune health.

DR. CHERRY LO, Ph.D

Longevity Expert

READ INTERVIEW

Dr. Cherry Lo, Ph.D., is a researcher specialising in pathology and immunity, with degrees from CUHK and the University of Hong Kong. Her work focuses on the interaction between NK cells and rheumatoid arthritis, providing new insights into disease mechanisms. As a research scientist, she contributes to advancements in longevity science. With a passion for immunology and translational research, Dr. Lo is dedicated to uncovering innovative solutions for age-related diseases and immune health.

DR. CHERRY LO, Ph.D

Longevity Expert

Ben is the founder and head grower at one of the UK’s leading fungi farms, where he cultivates a deep passion for mushroom cultivation and education. Since launching his farm in 2022, he has dedicated himself to exploring fungi’s medicinal and ecological potential. Ben is a regular speaker at functional mushroom conferences around the UK where he shares his knowledge and enthusiasm for the fungal kingdom. He aims to inspire others to connect with these fascinating organisms.

BEN GIBSON

Mycology Expert

Ben is the founder and head grower at one of the UK’s leading fungi farms, where he cultivates a deep passion for mushroom cultivation and education. Since launching his farm in 2022, he has dedicated himself to exploring fungi’s medicinal and ecological potential. Ben is a regular speaker at functional mushroom conferences around the UK where he shares his knowledge and enthusiasm for the fungal kingdom. He aims to inspire others to connect with these fascinating organisms.

BEN GIBSON

Mycology Expert

Carolina is a holistic sleep coach specialising in circadian biology, nutritional therapy, and biohacking. With over seven years of experience, she blends scientific research with ancestral wisdom to help clients achieve deep, restorative sleep naturally. Her expertise in light exposure, stress resilience, and nervous system regulation allows her to create personalised, sustainable solutions without reliance on medication. Carolina is passionate about empowering individuals to optimise their sleep and overall well-being through evidence-based, holistic practices.

CAROLINA RAMUSKI

Sleep Expert

Carolina is a holistic sleep coach specialising in circadian biology, nutritional therapy, and biohacking. With over seven years of experience, she blends scientific research with ancestral wisdom to help clients achieve deep, restorative sleep naturally. Her expertise in light exposure, stress resilience, and nervous system regulation allows her to create personalised, sustainable solutions without reliance on medication. Carolina is passionate about empowering individuals to optimise their sleep and overall well-being through evidence-based, holistic practices.

CAROLINA RAMUSKI

Sleep Expert